All Cases
Academic
Mendelian Randomization Causal Analysis
Project Question
An epidemiology group wanted to test causal hypotheses between lifestyle exposures and disease outcomes using genetic instruments to reduce confounding bias.
Analysis Approach
Selected genetic instruments from GWAS summary statistics, performed MR-Egger, Weighted Median, and Inverse Variance Weighted analyses. Assessed heterogeneity, pleiotropy, and sensitivity.
Input Data
- Exposure GWAS summary stats
- Outcome GWAS summary stats
- Instrument selection criteria
Deliverables
- Forest plot of causal estimates
- Funnel plot
- Leave-one-out sensitivity plot
- Heterogeneity and pleiotropy tests
- Methods report
Representative MR forest plot generated from mock data for layout demonstration.
This output represents the analytical approach and visualization style. Actual project results depend on input data quality, instrument strength, and underlying genetic architecture.